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Author(s):
Salvatore Brugaletta
,
Hector M Garcia-Garcia
,
Patrick W Serruys
Added:
3 years ago
The identification of vulnerable plaques has been a longstanding challenge for interventional cardiologists. Plaque composition is regarded as an important feature for assessment of plaque vulnerability. Histopathologists have in particular shown that the type of plaque most commonly prone to rupture in vivo is the thin-cap fibroatheroma (TCFA), in which the presence of lipid core (also called…
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Author(s):
Nienke S van Ditzhuijzen
,
Jurgen M Ligthart
,
Nico Bruining
,
et al
Added:
3 years ago
The indications for percutaneous coronary intervention (PCI) have expanded steadily during the past years. After the days of the revascularisation of obstructive coronary artery disease (CAD) by balloon angioplasty,1 the introduction of coronary stents has essentially contributed to PCI being one of the most frequently performed invasive therapeutic procedures worldwide. Bare metal stents (BMS)…
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Author(s):
Min Wu
,
Antonius FW van der Steen
,
Evelyn Regar
,
et al
Added:
3 years ago
Vulnerable atherosclerotic plaque comprises a lipid-rich necrotic core, covered by a thin fibrous cap, that is weakened by macrophage infiltration.1 Plaques that have this morphology and composition have a greater probability of being associated with acute coronary syndromes in clinical studies.2,3 Coronary artery disease is most commonly triggered by the rupture of vulnerable plaque and…
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Author(s):
Giuseppe Sangiorgi
,
Fabrizio Clementi
,
Clarissa Cola
Added:
3 years ago
Several independent lines of clinical evidence have shown that critical stenoses cause only a fraction of ACS. Rather, ruptures of a thin fibrous cap covering a large lipid-rich necrotic or superficial intimal erosion frequently trigger acute coronary thromboses at sites of non-critical narrowing of coronary arteries. This shift in thinking has fostered the notion of the so-called 'vulnerable' or…
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Author(s):
Steven P Marso
Added:
3 years ago
Adiponectin (also known as APM1, Acrp 30, AdipoQ or GBP28) is a 30kD circulating plasma protein and is the most abundant adipokine secreted by adipose tissue. In humans, adiponectin accounts for approximately 0.01% of circulating plasma proteins.1 It is thought to have a unique spectrum of properties for an adipokine, many of which are anti-atherosclerotic, and is downregulated in the presence of…
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Author(s):
Andrejs Erglis
,
Sanda Jegere
,
Inga Narbute
Added:
3 years ago
Intravascular ultrasound (IVUS) is the first catheter-based imaging modality that has been widely used in interventional cardiology.1 It creates cross-sectional images of the vessel lumen and the arterial wall and provides valuable diagnostic information to angiography regarding lumen and vessel measurements and plaque morphology. This information helps clinical decision-making in ambiguous…
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Author(s):
Gilles Rioufol
Added:
3 years ago
Coronary artery adventitia was long considered to be a purely supportive and nutritive tissue, and its role in the natural history of coronaropathy was thus neglected. However, recent studies have highlighted a dynamic role played by the adventitia, and especially by its vasa vasorum (VV), in the genesis of atherosclerosis,1–3 atherothrombotic events4,5 and restenosis following balloon…
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Author(s):
Fabrizio Fanelli
,
Emanuele Boatta
,
Pierleone Lucatelli
,
et al
Added:
3 years ago
Stroke is the third leading cause of death and permanent disability in the US and Europe. It is estimated that there are over 700,000 new cases of stroke each year in the US, of which 20–30% are thought to be secondary to carotid thromboembolic disease.1 In the last few years, carotid artery stenting (CAS) has significantly expanded as an alternative treatment to the conventional surgical carotid…
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Author(s):
Nitin Chandramohan
,
Jonathan Hinton
,
Peter O’Kane
,
et al
Added:
2 weeks ago
Author(s):
Yasushi Ueki
,
Tatsuhiko Otsuka
,
Kiyoshi Hibi
,
et al
Added:
3 years ago
Heavily calcified coronary artery lesions hinder device delivery and limit stent expansion, which is the most relevant predictor of stent failure. This may result in low procedural success and poor clinical outcomes. Coronary angiography has a limited ability to detect calcifications when planning an optimal percutaneous coronary intervention (PCI) strategy. Intracoronary imaging can provide…
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