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Author(s): Giuseppe Sangiorgi , Fabrizio Clementi , Clarissa Cola Added: 3 years ago
Several independent lines of clinical evidence have shown that critical stenoses cause only a fraction of ACS. Rather, ruptures of a thin fibrous cap covering a large lipid-rich necrotic or superficial intimal erosion frequently trigger acute coronary thromboses at sites of non-critical narrowing of coronary arteries. This shift in thinking has fostered the notion of the so-called 'vulnerable' or… View more

Prevention & Chronic Conditions

Intervention
Author(s): Min Wu , Antonius FW van der Steen , Evelyn Regar , et al Added: 3 years ago
Vulnerable atherosclerotic plaque comprises a lipid-rich necrotic core, covered by a thin fibrous cap, that is weakened by macrophage infiltration.1 Plaques that have this morphology and composition have a greater probability of being associated with acute coronary syndromes in clinical studies.2,3 Coronary artery disease is most commonly triggered by the rupture of vulnerable plaque and… View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Author(s): Gilles Rioufol Added: 3 years ago
Coronary artery adventitia was long considered to be a purely supportive and nutritive tissue, and its role in the natural history of coronaropathy was thus neglected. However, recent studies have highlighted a dynamic role played by the adventitia, and especially by its vasa vasorum (VV), in the genesis of atherosclerosis,1–3 atherothrombotic events4,5 and restenosis following balloon… View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Author(s): Salvatore Brugaletta , Hector M Garcia-Garcia , Patrick W Serruys Added: 3 years ago
The identification of vulnerable plaques has been a longstanding challenge for interventional cardiologists. Plaque composition is regarded as an important feature for assessment of plaque vulnerability. Histopathologists have in particular shown that the type of plaque most commonly prone to rupture in vivo is the thin-cap fibroatheroma (TCFA), in which the presence of lipid core (also called… View more

Imaging & Diagnostics
Renu Virmani
Research Area(s) / Expertise: Job title: President and Medical Director
Personal History Dr Renu Virmani was born in 1943 in Pakistan. Her father was an industrialist of Delhi and Amritsar, India.2 As the youngest girl in a family of ten children, Dr Virmani was always driven to stand out and excel. Her aunt, who was a neurologist, was instrumental in forging her ambitions to pursue medicine. “I admired her and she showed me that women can do whatever they want… View more
Author(s): Andrejs Erglis , Sanda Jegere , Inga Narbute Added: 3 years ago
Intravascular ultrasound (IVUS) is the first catheter-based imaging modality that has been widely used in interventional cardiology.1 It creates cross-sectional images of the vessel lumen and the arterial wall and provides valuable diagnostic information to angiography regarding lumen and vessel measurements and plaque morphology. This information helps clinical decision-making in ambiguous… View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Plenary Lecture: The Evolution of Cardiovascular Disease Worldwide: New Frontiers
Author(s): Valentin Fuster Added: 6 years ago

Heart Failure
ACC 23: Effect of Evolocumab on Coronary Plaque Morphology: The YELLOW III Study
Author(s): Annapoorna Kini Added: 1 year ago
ACC.23/WCC — Principle investigator of YELLOW III, Dr Annapoorna Subhash Kini(Mount Sinai Hospital, US) joins us to talk about the study that assessed the effect of evolocumab (Repatha) on coronary plaque morphology using intravascular imaging and gene expression analysis of peripheral blood mononuclear cells (PBMC) in 140 patients with stable CAD on maximally tolerated statin therapy … View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Precision Medicine in Interventional Cardiology
Author(s): Thijmen W Hokken , Joana M Ribeiro , Peter P De Jaegere , et al Added: 3 years ago
Evidence-based medicine is the foundation of contemporary clinical practice and results in better clinical outcomes than experience-based medicine.1 Meta-analyses of homogenous randomised controlled clinical trials are the pinnacle of evidence-based medicine and the backbone of the highest recommendations in clinical guidelines. These randomised trials pertain only to the selected patients who… View more

Imaging & Diagnostics

Digital Health