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Author(s): Brian G Hynes , Thomas J Kiernan , Nicholas J Ruggiero , et al Added: 3 years ago
Stroke-related morbidity and mortality remain unacceptably high. Recent estimates suggest that it accounts for approximately one out of every 17 deaths in the US, and that a person dies from the direct consequences of stroke every three to four minutes.1 Of the almost 800,000 strokes that occur annually, 87% are ischaemic, the remainder occurring predominantly as a consequence of intracerebral… View more

Intervention
Author(s): Eulogio García Fernandez , Didier Carrie , Amadeu Betriu , et al Added: 3 years ago
Drug-eluting stents (DES) have demonstrated their efficacy in reducing restenosis and repeated revascularisation.1–4 Some concerns related to DES safety (increased late stent thrombosis, difficulties with antiplatelet therapy compliance) and cost restrictions have encouraged interventional cardiologists to be selective in the use of DES and bare-metal stents (BMS).5–8 The latest generation of BMS… View more

Imaging & Diagnostics

Intervention
Percutaneous Closure of Patent Foramen Ovale
Author(s): Stefan Stortecky , Stephan Windecker Added: 3 years ago
Cerebrovascular events are associated with high rates of morbidity and mortality and are considered the global second leading cause of death.1 The majority of strokes are ischemic, although the etiology remains unknown in a considerable number of patients,2 commonly referred to as “non-defined” or “cryptogenic.”3 Data from epidemiologic studies point towards a relevant association between the… View more

Standards & Guidelines

Prevention & Chronic Conditions
Anti-thrombotic Therapy Following TAVI: UK and Ireland Consensus Statement
Author(s): Azfar Zaman , Bernard Prendergast , David Hildick-Smith , et al Added: 1 year ago

Anticoagulation
Author(s): Timm Bauer , Christian Hamm Added: 3 years ago
Introduction Antiplatelet therapy is a cornerstone in coronary artery disease (CAD) management. Acetylsalicyclic acid (ASA) has been known for many decades to have antithrombotic efficacy. Already in the 1980’s, the ISIS-2 study demonstrated that ASA reduces mortality in acute myocardial infarction (AMI) by 23 %.1 ASA leads to irreversible inactivation of cyclooxygenase 1 and thereby blocks the… View more

Anticoagulation
Author(s): Antonio L Bartorelli , Claudio Tondo Added: 3 years ago
On average, every 20 seconds someone in the US1 or in Europe2 has a stroke. This adds up to a total of about 1.7 million strokes per year in these two continents, affecting about 0.22% of the population each year. In the US alone, every four minutes someone dies from stroke, yielding a total mortality of about 140,000 deaths per year. As a result, stroke is the world’s third leading cause of… View more

Prevention & Chronic Conditions
Author(s): Paul Guedeney , Birgit Vogel , Roxana Mehran Added: 3 years ago
Dual antiplatelet therapy (DAPT) including aspirin and a P2Y12 inhibitor is the current gold standard for the treatment and mid-term secondary prevention of acute coronary syndrome (ACS).1–4 However, despite the use of potent P2Y12 inhibitors such as ticagrelor or prasugrel, patients remain at high ischaemic risk after ACS. More specifically, in the prasugrel treatment arm of the TRial to Assess… View more

Anticoagulation

MI/ACS
Author(s): Stuart J Head , Ad JJC Bogers , A Pieter Kappetein Added: 3 years ago
Valvular Heart Surgery The field of cardiac surgery is urgently in need of new anticoagulant agents. Approximately 300,000 prosthetic valves are implanted yearly, after which lifelong anticoagulation therapy is mandatory as thromboprophylaxis. To date, vitamin K antagonists (VKAs), such as warfarin, remain the only licensed agents to prevent mechanical valve-induced thromboembolic events but… View more

Anticoagulation

Vascular Disease and Surgery
Anticoagulation after Transcatheter Aortic Valve Implantation: Current Status
Author(s): Antonio Greco , Davide Capodanno Added: 3 years ago
Transcatheter aortic valve implantation (TAVI) is a valuable treatment option for patients with severe symptomatic aortic stenosis.1 Its use is supported by the results of multiple randomised controlled trials (RCTs) exploring the entire surgical risk spectrum, including inoperable, high-risk, intermediate risk and low risk patients.2–8 TAVI is associated with a small but not negligible… View more

Vascular Disease and Surgery

Intervention
Author(s): Gabriele Pesarini , Sara Ariotti , Flavio Ribichini Added: 3 years ago
Haemostasis is a complex phenomenon defined as the chain of mechanisms able to maintain the integrity of a closed, high-pressure circulatory system after vascular damage.1 Thrombogenesis represents the main process assuring haemostasis at each level of the vascular system, and its accurate regulation guarantees the correct balance between blood flow and damage repair. An uncontrolled thrombin… View more

MI/ACS

Intervention