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Author(s): Leif Thuesen , Niels Ramsing Holm Added: 3 years ago
Bifurcation lesions are frequent and account for about 15 % of all percutaneous coronary intervention cases.1 Bifurcations are a challenging lesion subset involving a main vessel (MV) and its side branch (SB). A bifurcation lesion may be looked upon as the proximal MV, the distal main vessel, the SB and the area of the bifurcation. Short- and long-term results depend on optimal handling of all… View more
Author(s): Nicolas Foin , Eduardo Alegria-Barrero , Ryo Torii , et al Added: 3 years ago
Drug-eluting stents (DESs) have contributed to a significant lowering of the incidence of restenosis and target vessel revascularisation (TVR) in bifurcations.1–4 A randomised study of bifurcation lesions using sirolimus-eluting stents revealed restenosis rates of only 4 % in the main branch (MB) and a TVR rate as low as 8.2 % at six-month follow-up,2 a marked improvement over that in historical… View more
Author(s): Shao-Liang Chen , Imad Sheiban Added: 3 years ago
Bifurcation lesions account for approximately 20–30% of all percutaneous coronary interventions (PCIs). Coronary bifurcation sites are prone to developing obstructive atherosclerotic disease due to turbulent blood flow and change of shear stress. With the complexity of bifurcation lesions, several classification systems have been advocated in order to extablish percutaneous strategies.1–3 In fact… View more
Author(s): Robin P Kraak , Maik J Grundeken , Robbert J de Winter , et al Added: 3 years ago
In the past three decades, significant progress has been made in the treatment of coronary artery disease. From the introduction of balloon angioplasty by Andreas Grüntzig in 19771 to metallic drugeluting stents with thin stent struts coated with cytotoxic or cytostatic drugs,2,3 with biocompatible/biodegradable polymers,4 with or without endothelial progenitor cell-capturing technology.5 However… View more
Author(s): Helen Routledge Added: 3 years ago
The preferred treatment approach for bifurcation disease can be generally summed up as ‘keep it simple’, otherwise known as provisional stenting. Based on several contemporary studies, coronary interventionalists have settled on a minimalist approach: starting with a single-stent approach for the main vessel (MV) and ignoring side branch (SB) disease unless clinical circumstances warrant… View more
Author(s): Ronan Ali , Adam B Greenbaum , Aaron D Kugelmass Added: 3 years ago
Abstract The basic equipment involved in percutaneous coronary interventions - guiding catheters, guide wires and dilation catheters (balloons) - have undergone significant evolution which has allowed for improvements in procedural success and safety. The coronary interventionalist should possess a thorough working knowledge of the available equipment and the ability to select specific equipment… View more
Author(s): Goran Stankovic , Zlatko Mehmedbegovic , Milorad Zivkovic Added: 3 years ago
Approximately 15–20% of percutaneous coronary interventions (PCIs) are performed to treat coronary bifurcations. These procedures are renowned for being technically challenging and historically have been associated with lower procedural success rates and worse clinical outcomes compared with non-bifurcation lesions.1,2 A bifurcation lesion is a lesion occurring at, or adjacent to, a significant… View more
Author(s): Oluseun Alli , David Holmes Jr Added: 3 years ago
Abstract Patients with complex and multivessel disease present challenging clinical problems in defining treatment strategies. The Synergy between PCI with taxus and cardiac surgery (SYNTAX) trial, which included both a randomised as well as a registry experience has clarified many issues. These include the extent and severity of the disease, the clinical presentation, and the metrics used for… View more
Author(s): Yves Louvard , Marie-Claude Morice , Thomas Hovasse , et al Added: 3 years ago
Due to anatomical reasons and the distributive function of the coronary tree, bifurcation sites are prone to the development of atherosclerotic lesions as a result of flow turbulence generating pro-atherogenous low wall shear stress (WSS). Over the past few years, coronary bifurcation lesions have been the subject of intense therapeutic discussions fuelled by new definitions, classifications … View more