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3 years ago
Recently, a novel type of interventional device has become available on the market: the drug-eluting balloon (DEB). The established performance of the percutaneous transluminal coronary angioplasty (PTCA) balloon catheter has been combined with the proven efficacy of antiproliferative drugs.
The usefulness of DEBs has been established,1–6 especially for treating in-stent restenosis (ISR), when…
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3 years ago
Since its introduction in 1977, the long-term benefits of percutaneous coronary intervention have been limited by the phenomenon of restenosis, i.e. the recurrence of significant stenosis at the site of intervention. While in restenosis after plain balloon angioplasty roughly two-thirds of the late lumen loss is due to negative vessel wall remodelling, the late lumen loss after stent implantation…
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3 years ago
The first-generation drug-eluting stents (DES) initially demonstrated good promise in terms of reducing the degree of restenosis. They succeeded in arresting the neo-intimal proliferation, which was the bane of coronary stents.1 Over a period of time, however, the polymeric degradation by-products failed to bring about an essential component of the healing process: endothelialisation. Failure of…
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3 years ago
Coronary stent implantation is one of the most important developments in the field of percutaneous coronary revascularisation after the introduction of balloon angioplasty in 1977.1 The treatment of coronary artery disease (CAD) using a bare-metal stent (BMS) is considered effective; however, restenosis occurs in 15–35% of all cases, requiring repeated treatment.2–4 To overcome the restenosis…
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3 years ago
Percutaneous coronary interventions (PCI) for the treatment of coronary artery obstructions are associated with a high rate of restenosis (20–57%) in the first six months after the procedure.1,2 Metallic stenting has significantly improved short-term procedural outcomes and reduced restenosis rates in patients undergoing PCI.3,4 The surgical stent deployment procedure initially involves the…
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3 years ago
Compared with conventional bare-metal stents (BMS), the introduction of drug-eluting stents (DES) has resulted in a substantial reduction in the incidence of in-stent restenosis.1 DES systems eluting either sirolimus2 or paclitaxel3 from a polymer stent coating have been shown in randomised trials to effectively inhibit the process of neointimal proliferation, resulting in restenosis reduction.
…
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3 years ago
First-generation Stents
Since drug-eluting stents (DES) received the CE mark in 2002 and the US Food and Drug Administration (FDA) approved the first DES in 2003, there has been a significant increase in the use of these devices. The advent of DES has revolutionised the field of interventional cardiology by having a major impact on patient care through their efficacy in reducing the need for…
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3 years ago
Proceedings of two satellite symposia held at EuroPCR, Paris in May 2015
Although the latest polymeric drug-eluting stents (DES) have enhanced percutaneous coronary intervention (PCI) procedures, a substantial proportion of patients requiring percutaneous transluminal coronary angiography (PTCA) is elderly with numerous different comorbidities. This population requires use of effective DES that…
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Advances in New Stent Designs without a Permanent Polymer May Solve Polymer-related Complications
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3 years ago
Article
Added:
3 years ago
Nearly one-third of the approximately 30 million people undergoing non-cardiac surgery in the US each year have known coronary artery disease (CAD) or CAD risk factors.1,2 An estimated one million suffer peri-operative cardiac complications accounting for roughly US$20 billion in annual medical costs.3 Peri-operative myocardial infarction (MI) may affect as many as 34% of high-risk individuals…
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