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Why, When and How Should Clinicians Use Physiology in Patients with Acute Coronary Syndromes?

… management and risk stratification. In this setting, the index of microcirculatory resistance emerged as an accurate tool to identify patients …

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Article

How to Diagnose and Manage Angina Without Obstructive Coronary Artery Disease: Lessons from the British Heart Foundation CorMicA Trial

… product) and myocardial supply:demand ratio (Buckberg index), are important. 12,13 Coronary factors are well … tests provide indirect assessments of myocardial resistance by assessing perfusion during exercise or … and microvascular resistance, typically using the index of microcirculatory resistance (IMR; Figure 2 ). Flow-limiting …

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Article

Is Hyperaemia Essential for Accurate Functional Assessment of Coronary Stenosis Severity?

… the contribution to inadequate myocardial blood flow of resistance in the stenotic large-calibre epicardial conduit … bolus injection. By rendering myocardial microvascular resistance constant and minimal, it is possible to separate … the 'wave-free' period. 9 It was proposed that coronary microcirculatory resistance was already constant in this …

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Article

Integrating Physiology into the DNA of Coronary Revascularisation – A Historical Perspective, Contemporary Review and Blueprint for the Future of Coronary Physiology

… This review will describe the physiological basis of this index, how it avoids the problems of existing indices such as … maximal hyperaemia. The most validated hyperaemia free index is iFR. 4 iFR is not dependent on maximal hyperaemia …

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Article

The Anatomic–Functional Duality of So-called ‘Significant’ Atherosclerotic Stenosis – Update on Invasive Diagnostic Strategies in Coronaropathy

… stenosis is dened by a simple binary morphological index of tightness - percent diameter stenosis (%DS > 50%). … inference drawn from a simple morphological index. So-called 'significant' atherosclerotic coronary … 10,11 Indices such as CFR or myocardial microvascular resistance index fail to answer the question as to whether an …

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Article

Fractional Flow Reserve Derived from Coronary Imaging and Computational Fluid Dynamics

… the need of a pressure wire would make this physiologic index become available to a wider population. Recent advances … interaction can be defined, whereas time-varying coronary resistance for each coronary branch can be determined … of the distal vascular system, such as small arteries, microcirculatory vessels and veins and returning blood to the …

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Article

Characteristics of Adiponectin and Coronary Plaque - An Intravascular Ultrasound Study

… lipoprotein (HDL) cholesterol, as well as insulin resistance, 2 type 2 diabetes, 3 lipid oxidation 4 and risk …

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Article

Fractional Flow Reserve: Does a Cut-off Value add Value?

… reuse of this content. Fractional flow reserve (FFR) is an index used to describe the physiological significance of a … conditions of minimal, constant coronary microvascular resistance, the pressure traces that we acquire with a … comprehensively validated as an invasive physiological index of ischaemia against other non-invasive modalities, …

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Article

Coronary Physiology Derived from Invasive Angiography: Will it be a Game Changer?

… of stenosis geometry, proximal pressure and microvascular resistance. This analysis demonstrated that accurate vFFR … the boundary conditions. Virtual Functional Assessment Index and Virtual Distal Coronary to Aortic Pressure Ratio … flow range was named the virtual functional assessment index (vFAI). This model was studied retrospectively in a …

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Article

Cardiac Unloading and the Kidney Cross-talk in Real Time

… maintained over 6 hours, whereas the systemic vascular resistance (SVR) gradually declined. Treatment with Impella … of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular …

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Article