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Author(s): Philipp Lurz , Karl Fengler Added: 3 years ago
The rise and fall of interventional renal sympathetic denervation (RDN) as a treatment for arterial hypertension is a remarkable chapter in the scientific history of the 21st century. This once promising therapy has been abandoned by most clinicians after the neutral results of the Renal Denervation in Patients With Uncontrolled Hypertension (SYMPLICITY-HTN3) trial.1 It would have been easy to… View more
Author(s): Joost Daemen , Added: 1 year ago
Ultrasound Renal Denervation (uRDN) is an innovative therapy option for the treatment of uncontrolled hypertension. uRDN therapy is delivered in a minimally invasive procedure that may lower high blood pressure by treating overactive renal nerves with ultrasound energy. This page provides an overview of uRDN technology and the latest evidence from its associated RADIANCE clinical program. … View more
Author(s): Ajay J Kirtane Added: 1 year ago
TCT 22 - In this short video from TCT 2022, Dr Ajay Kirtane (Columbia University Medical Center and New York-Presbyterian Hospital, NY, US) joins us to discuss the findings of ReCor's RADIANCE II Pivotal trial, which aimed to evaluate the safety and effectiveness of the Paradise renal Denervation System in patients with stage 2 hypertension. 225 patients were randomized to receive either a renal… View more
Author(s): Dominik Linz , Felix Mahfoud , Sebastian Ewen , et al Added: 3 years ago
The sympathetic nervous system regulates cardiac output, blood pressure (BP), heart rate and volume, electrolyte balance and composition of body fluids. The afferent signals to the brain are regulated by mechanosensitive baroreceptors, volume sensors and chemoreceptors located in the vessels and in many other organs, particularly in the heart, kidney, lung, brain and muscles. Sympathetic nervous… View more
Author(s): Lisa Brandon , Faisal Sharif Added: 3 years ago
Resistant hypertension remains a serious clinical burden despite significant advances in cardiology and healthcare. Hypertension is a chronic condition without any available cure, with significant associated morbidity and mortality, and necessitates lifelong use of medications. It is multifactorial in origin, associated with genetics, lifestyle factors and the metabolic syndrome. Resistant… View more
Author(s): Vikas Kapil , Ajay K Jain , Melvin D Lobo Added: 3 years ago
Up to one-in-five treated hypertensive patients are deemed to be treatment resistant1-3 (on at least three different anti-hypertensive medication classes, including a diuretic)4-6 and have high cardiovascular risk.7-9 There is a paucity of high-quality evidence to suggest that the addition of a fourth line (or fifth, sixth line, etc.) medication is likely to bring either hypertension under… View more
Author(s): Katrina Mountfort Added: 3 years ago
Hypertension is one of the most important public health problems of the 21st century, with a global prevalence of around 30 %.1 In 2010, it accounted for 7.5 million deaths worldwide, representing 12.8 % of the global total.2 Furthermore, its prevalence is projected to rise to 1.5 billion hypertensive patients in 2025.3 Despite the availability of numerous safe and effective antihypertensive… View more