EuroPCR 24: TAVR Vs SAVR in Younger Low-Risk Patients with Severe Aortic Valve Stenosis: NOTION-2

Published: 22 May 2024

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EuroPCR 24 - We are joined onsite by Prof Ole De Backer (Rigshospitalet, DK) to discuss the findings from the NOTION-2 Study. (NCT02825134).

NOTION-2 is a randomized, multicenter trial which aimed to investigate transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) in 376 patients under 75 years of age with severe aortic valve stenosis in regard to intra- and post-procedural morbidity and mortality rates, hospitalization length, functional capacity, quality of life and valvular prosthesis function. Patients were randomized 1:1 to receive either TAVR or SAVR, with 186 patients in each group.

Interview Questions:

  1. What is the background of this study?
  2. What was the patient population and study design?
  3. What are the key findings?
  4. What are the implications of these findings on clinical practice? What are the main take-home messages?
  5. Where are the knowledge gaps, and what are the next steps?

Recorded onsite at EuroPCR 2024, Paris.

Editor: Jordan Rance
Video Specialist: Dan Brent,
Interviewer: Bryony Wickens


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